Currently a postdoc in the group of Prof. Ivan Huc at the Ludwig Maximilians University of Munich, I am working on DNA mimics-proteins interactions. Previously, my PhD focused on photoactivatable first-row transition metal complexes for anticancer therapy and was carried out under the supervision of Dr. Kevin Cariou and Prof. Gilles Gasser at Chimie ParisTech – PSL.
New therapeutic strategies based on the inhibition of DNA-protein interactions using foldamers
Under the supervision of Prof. Dr. Ivan Huc – group website
• Protein expression and purification
• Protein/foldamer crystallization
• Protein/foldamer interaction studies (BioLayer Interferometry, Circular Dichroism)
• Molecular modelling of foldamers and docking with proteins (Maestro, Schrödinger)
• IT support of the group (Master user, cluster management)
• Social Media responsible: Bluesky account
• Lab duties (supervision of interns, apparatuses)
Exploring Transition Metal Complexes for Chemical Biology Applications
Under the supervision of Prof. Dr. Gilles Gasser and Dr. Kevin Cariou – group website profile
• Organic and inorganic synthesis + characterization techniques
• Cell cytotoxicity and phototoxicity measurements
• In vivo zebrafish toxicity studies
• Photooxidation assessment
• Lab duties (student representative of the lab, supervision of interns – from middle school to M2, managing solvents and consumables orders, in charge of lab apparatuses)
(1) Gourdon, L.; Cariou, K.; Gasser, G. Phototherapeutic Anticancer Strategies with First-Row Transition Metal Complexes: A Critical Review. Chem. Soc. Rev. 2022, 51 (3), 1167–1195. https://doi.org/10.1039/D1CS00609F. [Open access PDF (HAL)]
(2) Mani, A.; Feng, T.; Gandioso, A.; Vinck, R.; Notaro, A.; Gourdon, L.; Burckel, P.; Saubaméa, B.; Blacque, O.; Cariou, K.; Belgaied, J.-E.; Chao, H.; Gasser, G. Structurally Simple Osmium(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy in the Near Infrared. Angew. Chem. Int. Ed. 2023, 62 (20), e202218347. https://doi.org/10.1002/anie.202218347. [ChemRxiv link]
(3) Jakopec, S.; Gourdon-Grünewaldt, L.; Čipor, I.; Macan, A. M.; Perić, B.; Piantanida, I.; Cariou, K.; Gasser, G.; Kirin, S. I.; Raić-Malić, S. Synthesis, Characterisation and Biological Evaluation of Monometallic Re(I) and Heterobimetallic Re(I)/Fe(II) Complexes with a 1,2,3-Triazolyl Pyridine Chelating Moiety. Dalton Trans. 2023. https://doi.org/10.1039/D3DT01070H. [Open access PDF (HAL)]
(4) Gourdon-Grünewaldt, L.; Bakija, M.; Wild, L.; Gasser, G.; Perić, B.; Kirin, S.; Cariou, K. Towards Platinum(II) Complexes for in Cellulo Applications: Synthesis, Characterization, Biological and Catalytic Evaluation. Helv. Chim. Acta, 2023, e202300078. https://doi.org/10.1002/hlca.202300078. [Open Access PDF (HAL)]
(5) Gourdon-Grünewaldt, L.; Blacque, O.; Gasser, G.; Cariou, K. Towards Copper(I) Clusters for Photo- Induced Oxidation of Biological Thiols in Living Cells. Chembiochem, 2023, e202300496. https://doi.org/10.1002/cbic.202300496 - Open Access.
(6) Silva, M. J. S. A.; Zhang, Y.; Vinck, R.; Santos, F. M. F.; António, J. P. M.; Gourdon-Grünewaldt, L.; Zaouter, C.; Castonguay, A.; Patten, S. A.; Cariou, K.; Boscá, F.; Nájera, F.; Arteaga, J. F.; Gasser, G.; Pischel, U.; Gois, P. M. P. BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers That Induce Ferroptosis through Lipid Peroxidation. Bioconjug. Chem. 2023. https://doi.org/10.1021/acs.bioconjchem.3c00449. [Open Access PDF (HAL)]
(7) Zhou, L.; Salluce, G.; Mesdom, P.; Redrado, M.; Gourdon-Grünewaldt, L.; Hidalgo, S.; Blacque, O.; Arnoux, P.; Frochot, C.; Cariou, K.; Gasser, G. Synthesis, Characterization, and Biological Evaluation of Iron(III)-N-Heterocyclic Carbene Complexes as Photosensitizers for Photodynamic Therapy and Chemotherapeutics against Cancer. Inorg. Chem. 2025, 64 (33), 17058–17065. https://doi.org/10.1021/acs.inorgchem.5c03185.
In vivo phototoxicity evaluation on zebrafish of BASHY photosensitizers
INRS, Montréal, Canada / Apr. – May. 2023
Prof. Dr. Annie Castonguay
zebrafish (photo-)toxicity • in vivo fluorescence microscopy
Synthesis of Platinum(II) and Iron(III) complexes
Ruđer Bošković Institute / Oct. 2022
Prof. Dr. Srećko Kirin
synthesis of organometallic complexes
Copper complexes for photocatalysis
I-CLeHS, CNRS UMR 8060, Chimie ParisTech, Paris, France / Jan. – Jul. 2020
Prof. Dr. Gilles Gasser & Dr. Kevin Cariou
inorganic synthesis (complexes and clusters) • photooxidation studies • cell culture
Computational study of betulin and derivatives – highly potent anticancer agents
Novosibirsk State University, Russia / Apr. – Jun. 2019
Dr. Denis Rychkov
supercomputers (SSH protocols) • DFT softwares (VASP, Gaussian 09) • databases (CCDC, PDB)
In vivo studies of piano-stool ruthenium compounds
Laboratoire des Biomolécules, ENS/UPMC/CNRS UMR 7203, Paris, France / Jan. - Mar. 2019
Prof. Dr. Clotilde Policar
Ru complexes synthesis • cell culture and cytotoxicity studies
Inorganic click reaction between a functionalized peptide and ruthenium & osmium complexes
Julius-Maximilians Universität Würzburg, Germany / Mar. – Jul. 2018
Prof. Dr. Ulrich Schatzschneider
peptide synthesis • Os and Ru piano-stool complexes synthesis • inorganic click reactions
Synthesis and analysis of sodium-substituted nanohydroxyapatites
Mendeleev Institute of Moscow, Russia / Jun. – Jul. 2017
Prof. Dr. Marina Koroleva
synthesis of nanohydroxyapatites • zeta potential measurement • IR
Increasing the performance of n-type dye sensitized solar cells by testing new inorganic dyes and alternative redox couples
Newcastle University, UK / Jun. – Jul. 2016
Dr. Elizabeth Gibson
synthesis of electrolytes and dyes • electrochemical and spectroscopic characterization
Re(CO)3 multimodal sensors: synthesis and IR sub-cellular imaging
Laboratoire des Biomolécules, ENS/UPMC/CNRS UMR 7203, Paris, France / Dec. 2015
Prof. Dr. Clotilde Policar
peptide synthesis • synthesis of rhenium complexes • IR cartographies of cells (Synchrotron Soleil)
• Forthcoming: ChemBio Paris 2025 – Paris, France [organizing comittee as co-founder of the French Young ChemBio group]
• International Foldamer Symposium 2025 – London, UK
• Workshop on Foldamers – Bordeaux, France
• Munich PostDoc Night 2024: Interdisciplinary Conference for Postdocs – Munich, Germany
• Supr@Paris: International Conference on Supramolecular Chemistry – Paris, France
• ISBOMC 2023: International Symposium on Bioorganometallic Chemistry – Braunschweig, Germany
• French PDT Day 2023: Symposium on Photodynamic Therapy – Paris, France
• ISBOMC 2022: International Symposium on Bioorganometallic Chemistry – Paris, France
• French PDT Day 2021: Symposium on Photodynamic Therapy – Toulouse, France
French (mother tongue) / English (C1) / German (C1) / Russian (B1)
2023 – PhD in Molecular Chemistry – Paris Sciences et Lettres (PSL) University
2020 – Master in Chemistry and Life Sciences – Paris Sciences et Lettres (PSL) University
2020 – Master in Chemistry – École Normale Supérieure de la rue d’Ulm (ENS), Paris, France
2017 – Bachelor degree in Chemistry – Sorbonne Université, Paris, France
2019-2020 – Master of Chemistry and Life Sciences. Paris Sciences et Lettres (PSL) University, Paris, France
2015-2020 – Predoctoral Formation of the École Normale Supérieure. École Normale Supérieure de la rue d’Ulm (ENS), Paris, France
2013-2015 – Preparatory class (mathematics, physics and chemistry). Lycée Marcelin Berthelot, Saint-Maur des Fossés, France
ChemBioDraw Office • Schrödinger Maestro basics • AlphaFold • GraphPad Prism • Server installation • Gaussian 9 • Adobe Illustrator • LateX • Linux • HTML • Cryptology introduction • Various lab softwares
2024-2025 – Practical course Teacher at LMU : practical work for Pharmacy students in 2nd semester
Supervision, correction of notebooks, teaching of practical skills
2020-2023 – Practical course Teacher at ENSCP-PSL : practical work for ChimieParisTech students (bachelor and master, for 3 years during PhD)
Supervision, correction of practical notebooks and articles, teaching of practical skills, numerical and bibliographical tools
2020 – Physics and chemistry high school teacher
Part-time replacement for senior year of the high school Albert de Mun (Nogent-sur-Marne), with classes in English (Euro option)
2012-2019 – Private tutoring in mathematics, physics and chemistry
Middle school, high school, undergraduate degree
2017-2019 – Animation of intensive summer refresher courses
High school level: physics-chemistry, mathematics, science and technology
2016-2017 – TalENS: Tutoring program
Physics and chemistry lessons given over a year to students from disadvantaged high schools
2015-2017 – Private tutoring in French and German
Middle and high school level
2015-2016 – Tutoring and practical work for the preparation of the International Chemistry Olympiads
Chemistry classes at the high school level and first year of preparatory school (PCSI)
2013-2015 – Cordées de la réussite: Tutoring program
Tutoring of students from disadvantaged high schools by students from preparatory classes
2024 – Publication in L’Actualité Chimique
Article on Photodynamic Therapy written with Francisca Figuereido, published in a french journal popularizing chemistry – link
2023 – Participation to the podcast “Heavy metal”
Podcast PSL University, by Yann Plantier (participation in the 3rd part) – link in French, start at 17’.
2022 – Interview on the occasion of the International Women's Rights Day
Short interview on Chimie ParisTech website to explain what it means to be a woman of science today – link in French.
2021 – Short film “Metalhead” – Symbiose competition
Short film about my PhD for the film festival Pariscience – competition in 48h – link in French, english subtitles on demand.
2019 – Educational videos "Interros des lycées"
Physics and chemistry videos produced for the new high school programs; for Prepamath and Nathan publishing houses – example here in French.
2016 – Theater piece “When Pasteur was a chemist”
Theater piece played by Eric Ruf (Comédie française), students from the ENS and Clotilde Policar – Théâtre de la Reine Blanche, link in French.
